Diphenoxylate: Uses, Side Effects, and Precautions

Diphenoxylate is an antidiarrheal medication that is used to treat diarrhea caused by certain types of bacteria. It works by slowing down the movement of the gut and increasing the amount of water that is absorbed from the stool, which helps to firm up the stool and reduce the frequency of bowel movements.

Diphenoxylate is available over-the-counter (OTC) in the United States and is often combined with atropine, a medication that helps to slow down the movement of the gut, to form a combination product called Lomotil. It is important to note that diphenoxylate should only be used under the guidance of a healthcare provider, as it can have serious side effects if used improperly or in certain individuals.

Diphenoxylate has been associated with a number of side effects, including:

* Constipation
* Abdominal pain
* Nausea and vomiting
* Headache
* Dizziness
* Fatigue
* Allergic reactions, such as hives or difficulty breathing

In rare cases, diphenoxylate can cause more serious side effects, including:

* Severe allergic reactions
* Intestinal blockage or obstruction
* Inflammatory bowel disease (IBD)
* Irritation of the esophagus and stomach

It is important to follow the dosage instructions carefully and to talk to your healthcare provider before taking diphenoxylate if you have any medical conditions, such as kidney disease, liver disease, or a history of inflammatory bowel disease. Additionally, it is important to avoid taking diphenoxylate for prolonged periods of time, as this can increase the risk of side effects.