Understanding Epineural: The Outer Layer of Peripheral Nerve Sheath

Epineural refers to the outer layer of the peripheral nerve sheath, which is a protective covering of connective tissue that surrounds and supports the nerve fibers. The epineurium is composed of collagenous fibers and serves to protect the nerve from mechanical damage and to maintain the proper environment for the nerve fibers to function properly.

In addition to providing mechanical support, the epineurium also plays a role in the regulation of the immune response and inflammation within the peripheral nervous system. It acts as a barrier to prevent immune cells and other substances from entering the nerve and damaging the nerve fibers.

The term "epineural" is used in various medical contexts, including neurology, neurosurgery, and pain management. For example, epineural catheters are used to deliver pain medication directly to the site of the nerve, and epineural surgery refers to surgical procedures that involve the removal or repair of the epineurium.